Leafly Buzz: 12 Hottest Weed Strains as of May 2021

With over 248 million vaccinations in its arms and summer approaching, America’s desire for a normal life is reaching critical levels.

Keeping up with our excitement this May, cannabis breeders, growers, and sellers keep pumping out wet delicacies like ZimZims, Whoa-Si-Whoa, and Quest. And who has the details? Leafly.

Regardless of fear and favor, Leafly Buzz reports on premium cannabis strains and branded flower products that are new to the shelf, trending, and sold out west of the Rockies.

Sit back, pack one and off you go!

Data grinder

Blade Buzz Data Grinder


A photo of Orangeade bred by Rimrock Farms via the Green Cross (David Downs / Leafly)Refreshing orangeade grown by Rimrock Farms, via The Green Cross San Francisco. (David Downs / Leafly)

It’s morning in America and we’re chugging Orangeade. Get some sweet, citrusy, and grape-colored THC to do the weekend jobs with this strain.

Symbiotic Genetics of California crossed Tangie and Purple Punch to make this hit hybrid. Strain traffic to Orangeade has increased by 14% month on month, which is very close to its cousin Mimosa (plus 13%). Both are perfect for the first girls weekend.

A photo by Mimosa (David Downs / Leafly)Bottoms up: Mimosa from Symbiotic Genetics. (David Downs / Leafly)

Speaking of Tangie Cross, Ethos Genetics’ Chemdog, I-95, Mandarin Cookies Cross, Crescendo, this month increased search volume by 89%.

On the retreat: Cult Classic Seeds’ Cement Shoes falls 23% as Americans postpone somnambulatory signs of pandemic hibernation.

Here is the full data grinder:

● Orangeade ⬆️ + 14%

● Mimosa ⬆️ + 13%

● Crescendo ⬆️ + 89%

● cement shoes ⬇️ -23%

New in the Leafly master database

Every month Leafly adds dozens of new varieties to our master database. Connoisseurs long for the flavors and effects of these new crosses made from Zkittlez, Do-Si-Dos and Gelato.


A photo by CAM ZimZims 2021 (David Downs / Leafly)Seed Junky Genetics-bred and CAM-bred ZimZims are scheduled for May. (David Downs / Leafly)

Try the top of the rainbow with this zkittlez crossed for yourself. ZimZims is bred by Seed Junky Genetics of Los Angeles and bred to perfection by the women-run Colorado transplant CAM in Sacramento. The smell and taste of ZimZim’s tropical sweets and Trix muesli is as good as the bud looks. Perfect for perfuming your first garden grill.

Project 4516

A photo from Grandiflora Project 4516 (David Downs / LeaflySecret weapon: Grandiflora’s Project 4516. (David Downs / Leafly)

Mysteriously named with an elite gelato flavor, Project 4516 combines Gelato 45 and the rare Platinum Puff. This premium strain from California indoor chefs Grandiflora promises gaseous biscuits perfect for smoothing out plot gaps in films like Godzilla vs. Kong.


A photo of Who Si Whoa Bud Low Res (courtesy Top Shelf Cultivation)Whoa Si Whoa. (Courtesy Top Shelf Cultivation)

If you like Do-Si-Dos, watch out for Whoa-Si-Whoa. Whoa-Si-Whoa was bred by Cannarado of Colorado and selected by Top-Shelf Cultivation in California. In 2019 he received a Cannabis Cup. Expect a big OG Kush bite and funk from this reinforced dose. Great for appreciating the special effects of the new Mortal Kombat. Finish him!

Modified grapes

A photo of modified grapes.  (Courtesy LitHouse)Modified grapes. (Courtesy LitHouse)

Save up for this sweet and savory treat that will get you on the couch. Compound Genetics of California crossed GMO to Purple Punch for this powerful combination of meaty onions and fruit, perfected by breeders LitHouse. Modified grapes are great as a digestif after your first outdoor dining experience in 2021.

Stress highlights from May

leafy hum of new varieties

New on the pharmacy shelves –Diablo wind from Houseplant, CA.

A photo of houseplant Diablo Wind.  (David Downs / Leafly)Houseplant’s Diablo Wind has Jack Terps and Energy. (David Downs / Leafly)

Actor Seth Rogen’s California launch of Houseplant defied critics on Celebrity Weed for delivering big, terpy, fantastic, top-notch indoor nugs. Now all three houseplant stems pass the pattern in 17 inviting pharmacies.

Diablo Wind offers a bright, energetic counterpoint to all of the cookies out there. Diablo Wind is Jack Herer x G13 Haze. It’s similar to XJ-13, and this stuff is great for daytime activities – like a pottery class!

The charts are skyrocketing –Grape octane from Alibi, OR

A close up of Alibi Farms grape octane macro (courtesy Alibi Farms; photo by resinned_lens)A dazzling close-up of Alibi Farms Grape Octane (courtesy of Alibi Farms; photo by @resinierte_Linse)

Alibi Farms in Clackamas, Oregon, owned by women, continues to deliver indoor quality to discerning smokers in Beaver State. Their entire lineup is real, but Cannarado Genetics’ cross of High Octane OG and Grape Pie is a guaranteed winner.

The gaseous diesel smell suggests grapes and fruit and goes well with the Kardashians’ final season or a trance-like Minecraft marathon.


Leaf buzz bestseller

Ballin out –search from Source, CA.

A photo of Source's Tribes Quest on the branch.  (Courtesy Source)Quelle Cannabis Grows Quest in-house. (Courtesy of Source)

The search for the perfect interior space in California is over at Source Cannabis. Source’s flagship strain is a variety of Original Glue (also known as GG4; a cross of Chem Sister, Sour Dub, and Chocolate Diesel) bred by GG Strains. Buttery lemon and pungent pine aroma give this strong strain a boost that goes well with chill hobbies like spring gardening or zoom poker.

In laboratory tests, GG4 is rich in astringent pinene aroma, aided by moist myrcene and caryophyllene.

Ballin ‘on a budget –Lemon cane YOLO, from Archive CA.

A photo of Lemon Cane Yolo (David Downs / Leafly)Penny Pinchers are happy: Lemon Cane YOLO. (David Downs / Leafly)

From Yolo County, CA, this outdoor-grown bargain flower keeps giving us life. Archive Seeds from Oregon, California crossed a lemon peel with a Do-Si-Dos for thick lemon syrup-flavored drops with a mega-body-fuel finish. The outdoor product (called “YOLO”) can compete with indoor products in terms of value, terps and effects.

It’s great for numbing the mind and browsing 1,000 unread emails. Better yet – delete them all and set your vacation reply to “YOLO”.

Reeds hum high note

A photo of Kalya Patty Cake rosin on swab.  (David Downs / Leafly)A photo of Kalya Patty Cake rosin on a puffco swab. (David Downs / Leafly)

Prepare yourself for a premium extract that will stone you to the core. Kalya extracts from Oakland took 1st, 4th and 8th place in the Emerald Cup in April in solvent-free extracts and won with Patty Cake, a cross between a wedding cake, and Gelato # 33 from Landhammer Farms. Landhammer gently froze freshly harvested buds, then Kalya rinsed the plant’s trichomes with ice water and coldly squeezed and filtered the pure resonance.

The result looks like a science fiction metamaterial and smells like the extracted soul of the flower: rich, deep and sweet with GSC terps. Keep that expensive hashish sealed and frozen below 32 degrees and wait 15 minutes for the translucent pie to reach room temperature before opening it and dabbing it at low temperatures. Then meditate silently in the forest for hours. Delivery by Zenganic Delivery in Oakland.

Buzz-back problems

The flow of cannabis strains never stops flowing. Step onto the same river twice – read our previous West Coast Fire Flower summaries.

Catching up March’s buzz

Love lemon tree?  Go even more bling with Lemonatti.  (David Downs / Leafly)Love lemon tree? Go even more bling with Lemonatti. Sold by The Green Cross, SF. (David Downs / Leafly)

Do not miss February’s buzz

Alien Labs Crypto Chronic (David Downs / Leafly)Alien Labs’ Krypto Chronic goes to the moon. (David Downs / Leafly)

Relive again January’s buzz

Connected Gelonade is the best indoor flower of the Emerald Cup in 2021. (David Downs / Leafly)Connected Gelonade is the best indoor flower of the Emerald Cup in 2021. (David Downs / Leafly)

Repetition November’s buzz

Slurricane by SF Cultivators sold by Mission Organic Center (David Downs / Leafly).Slurricane by SF Cultivators sold by Mission Organic Center (David Downs / Leafly).

review October’s buzzand read along.

What’s in Leafly Buzz?

Who decides what’s in the buzz? Not money or compliments. Each month’s Leafly Buzz Picks are from:

  • Secret purchases in stores
  • Leafly staff and reader tips
  • Interview with the biggest brands
  • Analyze Leafly Search Data
  • Lurking breeders on Instagram

Breeders, growers, brands, stores – do you fancy Leafly? We are all ears. Email us at Buzz@leafly.com.

David Downs

David Downs directs news and lifestyle coverage as chief of the California Bureau for Leafly.com. He has written for WIRED, Rolling Stone and Billboard and is the former cannabis editor of the San Francisco Chronicle and author of several cannabis books including ‘Marijuana Harvest’ by Ed Rosenthal and David Downs. He is the co-host of the Hash Podcast. TW: @davidrdowns | IG @daviddowns

Show article by David Downs

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